Anthony Bretscher, Ph.D.
for Cell and Molecular Biology
Department of Molecular Biology and Genetics
257 Weill Hall
Ithaca, NY 14853-7202
The Bretscher lab studies how microfilaments contribute to the functional organization of eukaryotic cells. Two model systems are used.
In the first, we investigate the role of actin binding proteins in the functional organization of the apical aspect of polarized epithelial cells. This work is currently centered around ezrin, and has lead us to investigate both signaling and membrane traffic pathways.
In the second, we exploit budding yeast to understand how the actin cytoskeleton polarizes secretion and segregates organelles during the cell cycle. The current focus is on the role of formins and myosin-V motors.
To learn more about our research, click here.
- PNAS - New Paper: Deconstructing formin-dependent actin cable assembly. Bretscher, A. (Nov. 2013)
- Curr Biol. - New Paper: Active Segregation of Yeast Mitochondria by Myo2 Is Essential and Mediated by Mmr1 and Ypt11. Chernyakov I, Santiago-Tirado F, Bretscher A. (Sept. 2013)
- Mol Bio Cell - New Paper: Magazine or journal—what is the difference? The role of the monitoring editor. Bretscher, A. (April 2013)
- J. Cell Biol. - New Paper: Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells. Viswanatha, R., Ohouo, P., Smolka, M., Bretscher, A. (December 2012)
- Dev. Cell - New Paper: Myosin-V Is Activated by Binding Secretory Cargo and Released in Coordination with Rab/Exocyst Function. Donovan, K. ,Bretscher A. (October 2012)
- J. Cell Biol. - New Paper: PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli. Garbett D. ,Bretscher A. (July 2012)
- J. Cell Biol. - New Paper: Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans.Mi-Mi L., Votra S., KemphuesK ., Bretscher A., Pruyne D. (July 2012)
- Dev. Cell - New Paper: The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State. Sher I, Hanemann O, Karplus AP, Bretscher A. (April 2012)
- Mol. Biol. of Cell - New Paper: EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. Hokanson, DE, Bretscher, A. (January 2012)
- Mol. Biol. of Cell - New Paper: Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation. Liu W, Santiago-Tirado FH, Bretscher A. (January 2012)
- Trends Cell Biol.: Membrane-trafficking sorting hubs: cooperation between P14P and small GTPases at the trans-Golgi network. Santiago-Tirado FH, Bretscher A. (July 2011)
- Dev. Cell: P14P and Rab Inpurts Collaborate in Myosin-V-Dependent Transport of Secretory Compartments in Yeast. Santiago-Tirado FH, Legesse-Miller A, Schott D, Bretscher A. (January 2011)
- J. Biol. Chem. : The UBX Protein SAKS1 negatively regulates ERAD and p97-dependent degradation. Lalonde DP, Bretscher A. (December 2010)
- J. Cell Biol.: The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner. Garbett D, Lalonde DP, Bretscher A. (October 2010)
- Nat. Rev. Mol. Cel Biol.: Organizing the cell cortex: the role of ERM proteins. Fehon, R.G., McClatchey A.I., Bretscher A. (April 2010)
- MBC: The yeast formin bnr1p has two localization regions that show spatially and temporally distinct association with septin structures. Gao, L., Liu, W., Bretscher, A. (April 2010)
- MBC: A Regulated Complex of the Scaffolding Proteins PDZK1 and EBP50 with Ezrin Contribute to Microvillar Organization. Lalonde, D.P., Garbett, D., Bretscher, A. (March 2010)
- Anthony Bretscher honored as AAAS fellow
December 17, 2009
Anthony Bretscher, Associate Director of the Weill Institute, has been named a fellow of the American Association for the Advancement of Science. More..
- Molecular Cell Biology, 6e. Lodish H, Berk A, Kaiser, C, Krieger M, Scott M, Bretscher A, Ploegh H, Matsudaira P. (August 2007)
- Molecular Cell Biology, 7e. Lodish H, Berk A, Kaiser, C, Krieger M,Bretscher A, Ploegh H, Amon, A, Scott, M. (2012)