Anthony Bretscher, Ph.D.
Weill Institute
for Cell and Molecular Biology
Department of Molecular Biology and Genetics
Cornell University
435 Weill Hall
Ithaca, NY 14853-7202
apb5@cornell.edu
(607)255-5713 (Office)
(607)255-5709 (Lab)
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News
- Nature Immunology - New Paper: T cell antigen receptor siglaning and immunological synapse stability require myosin IIA. Ilani, T., Vasiliver-Shamis, G., Vardhana, S., Bretscher, A., Dustin, M.L. (April 2009)
- MBC - New Paper: Polarized growth in budding yeast int he absence of a localized formin. Gao, L., Bretscher, A. (March 2009)
- Biochemistry - New Paper: The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50. Lalonde, D., Bretscher, A. (January 2009)
- MBC - New Paper: Analysis of Unregulated Formin Activity Reveals How Yeast Can Balance F-Actin Assembly Between Different Microfilament-Based Organizations. Gao, L., Bretscher, A. (January 2008)
- Molecular Cell Biology, 6e. Lodish H, Berk A, Kaiser, C, Krieger M, Scott M, Bretscher A, Ploegh H, Matsudaira P. (August 2007)
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The Bretscher lab studies the functional role of microfilaments in eukaryotic cells. Two model systems are used.
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In the first, we investigate the role of actin binding proteins in the functional organization of the apical aspect of polarized epithelial cells. This work is currently centered around ezrin, and has lead us to investigate both signaling and membrane traffic pathways. We are also exploring the role of the ezrin family of proteins during immune synapse formation.
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In the second, we exploit budding yest to understand how the actin cytoskeleton polarizes secretion and segregates organelles during the cell cycle. The current focus is on the role of formins and myosin-V motors.
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To learn more about our research, click here. |
