Jan Lammerding, Ph.D.
Weill Institute for Cell &
and Department of Biomedical Engineering
235 Weill Hall
Ithaca, NY 14853-7202
- December 2013. Samantha Olyha, an undergraduate student in the Lammerding Lab, was awarded a prestigious Marshall Scholarship to study at Oxford University.
- November 2013. Gabriel Lopez, who worked as a summer REU student in the Lammerding Lab, won an Outstanding Presentation Award/Certificate of Achievement in the Engineering, Physics and Mathematics category for his poster “Designing a Microfluidic Device to Study the Deformability of Cancer Cells” at the 2013 Annual Biomedical Research Conference for Minority Students (ABRCMS) in Nashville, TN.
- October 2013.The Cornell Daily Sun featured an article highlighting the interdisciplinary research in the Lammerding laboratory that addresses the role of cellular biomechanics in a variety of human diseases ranging from muscular dystrophy to premature aging and cancer. See: Cornell Researcher Investigates Nuclear Mutations.
- August 2013. Greg Fedorchak, a BME PhD student in the Lammerding lab, was awarded a BMES Student Travel Grant to attend the 2013 BMES Annual Meeting in Seattle, Washington.
- June 2013. Jan Lammerding received an NSF CAREER Award to study the role of nuclear biomechanics during cell migration in 3-D environments.
- June 2013. Dennis Chua, an undergraduate student in the Lammerding Lab, was awarded a Tau Beta Pi Scholarship for 2013-14.
- June 2013. Chin Yee Ho was awarded a prestigious postdoctoral fellowship from the American Heart Association.
- May 2013. Chin Yee Ho’s work on the interplay between lamin A/C, emerin, and myocardin-related transcription factor-A (MRTF-A) was just published in Nature: Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J. Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature 2013 May 23;497(7450):507-11. doi: 10.1038/nature12105.
- April 2013. Greg Fedorchak was awarded an NSF GK-12 fellowship in Biomedical Engineering to work with teachers and students in K-12 schools to enrich science, technology, engineering and mathematics (STEM) content and instruction for underserved local schools.
- February 2013. Our article describing the effect of specific disease-causing lamin mutants on nuclear mechanics in vitro and in vivo was accepted for publication: Zwerger M, Jaalouk D, Lombardi M, Isermann P, Mauermann M, Dialynas G, Herrmann H, Wallrath L, Lammerding J. Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling. Hum. Molecular Genetics. 2013 Jun 15;22(12):2335-49. doi: 10.1093/hmg/ddt079.
- February 2013. Undergraduate student Shen Ning received a competitive fellowship from the Cornell Oxford Study Abroad Program to spend her junior year at Oxford University, starting in fall 2013.
- January 2013. Our article describing the importance of lamin A in neutrophil deformability was published: Rowat AC, Jaalouk DE, Zwerger M, Ung WL, Eydelnant IA, Olins D, Olins A, Herrmann H, Weitz DA, Lammerding J. Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions. J. Biol Chem. 2013 Jan. 288(12):8610-8. doi: 10.1074/jbc.M112.441535.
The Lammerding lab is focused on subcellular mechanics and the cellular signaling response to mechanical stimulation.
The research in Dr. Lammerding’s group is focused on developing and applying novel experimental techniques to explore the interplay between cellular structure and function, with a particular emphasis on the cell nucleus and the nuclear envelope. Recent discoveries provide compelling evidence that the physical properties of the nucleus are critical for a multitude of cellular functions, and that defects in nuclear structure and organization can contribute to a large number of human diseases, ranging from muscular dystrophies and cardiomyopathies to premature aging and cancer. While many of the projects in our laboratory are aimed at elucidating the molecular mechanisms underlying human diseases caused by mutations in nuclear envelope proteins, our research will also provide important insights into the normal functions of these proteins.
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