Four Cell photos

Institute Publications


Ling Y, Stefan CJ, Macgurn JA, Audhya A, Emr SD. The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P(2) synthesis. EMBO J. (2012)

Wood CS, Hung CS, Huoh YS, Mousley CJ, Stefan CJ, Bankaitis V, Ferguson KM, Burd CG. Local control of PtdIns4P signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase. Mol. Biol. Cell. (2012)

Richardson BC, McDonold CM, Fromme JC. The Sec7 Arf-GEF Is Recruited to the trans-Golgi Network by Positive Feedback. Dev. Cell. (2012)

Sher I, Hanemann O, Karplus AP, Bretscher AP. The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State. Dev. Cell. (2012)

Blake-Hodek KA, Williams BC, Zhao Y, Castilho PV, Chen W, Mao Y, Yamamoto TM, Goldberg ML. Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry. Mol Cell Biol. (2012)

Zhong S, Hsu F, Stefan CJ, Wu X, Patel A, Cosgrove MS, Mao Y. Allosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids. Biochemistry. (2012)

Nepusz T, Yu H, Paccanaro A. Detecting overlapping protein complexes in protein-protein interaction networks. Nat Methods. (2012)

MacGurn JA, Hsu PC, Emr SD. Ubiquitin and Membrane Protein Turnover: From Cradle to Grave. Annu Rev Biochem. (2012)

Macdonald C, Buchkovich NJ, Stringer DK, Emr SD, Piper RC. Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation. EMBO Rep. (2012)

Bastos de Oliveira FM, Harris MR, Brazauskas P, de Bruin RA, Smolka MB. Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes. Embo J. (2012)

Travesa A, Kuo D, de Bruin RA, Kalashnikova TI, Guaderrama M, Thai K, Aslanian A, Smolka MB, Yates JR 3rd, Ideker T, Wittenberg C. DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1. EMBO J. (2012)

Fromme JC, Kim J. A rapid and quantitative coat protein complex II vesicle formation assay using luciferase reporters. Anal Biochem. (2012)

Wang X, Wei X, Thijssen B, Das J, Lipkin SM, Yu H. Three-dimensional reconstruction of protein networks provides insight into human genetic disease. Nature Biotechnol. (2012)

Hokanson, DE, Bretscher, A. EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. Mol. Biol. of Cell. (2012)

Liu W, Santiago-Tirado FH, Bretscher A. Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation. Mol. Biol. of Cell. (2012)



Karotki, L. JT Huiskonen, CJ Stefan, NE Ziolkowska, R Roth, MA Surma, NJ Krogan, SD Emr, J Heuser, K Grunewald & TC Walther. Eisosome proteins assemble into a membrane scaffold. J. Cell Biol. (2011)

)MacGurn, JA, PC Hsu, MB Smolka & SD Emr. TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor. Cell. (2011)

Ripoll JJ, Roeder AH, Ditta GS, Yanofsky MF. A novel role for the floral homeotic gene APETALA2 during Arabidopsis fruit development. Development. (2011)

Lombardi ML, Lammerding J. Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function. Biochem Soc Trans. (2011)

Shi, Y, CJ Stefan, SM Rue, D Teis & SD Emr. Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol. Biol. Cell. (2011)

Wang X, Gulbahce N, Yu H. Network-based methods for human disease gene prediction. Brief Funct Genomics. (2011)

Xue Z, He Y, Ye K, Gu Z, Mao Y, Qi L. A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha. J Biol Chem. (2011)

Santiago-Tirado FH, Bretscher A. Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network. Trends Cell Biol. (2011)

Lombardi ML, Zwerger M, Lammerding J. Biophysical assays to probe the mechanical properties of the interphase cell nucleus: substrate strain application and microneedle manipulation. J Vis Exp. (2011)

Booth JG, Eilertson KE, Olinares PD, Yu H. A bayesian mixture model for comparative spectral count data in shotgun proteomics. Mol Cell Proteomics. (2011)

McMurray, MA, CJ Stefan, M Wemmer, G Odorizzi, SD Emr & J Thorner. Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis. Biol. Chem. (2011)

Henne, WM, NJ Buchkovich & SD Emr. The ESCRT Pathway. Dev. Cell. (2011)

Zheng Y, Brady OA, Meng PS, Mao Y, Hu F. C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking. PLoS One. (2011)

Ghamsari L, Balaji S, Shen Y, Yang X, Balcha D, Fan C, Hao T, Yu H, Papin JA, Salehi-Ashtiani K. Genome-wide functional annotation and structural verification of metabolic ORFeome of Chlamydomonas reinhardtii. BMC Genomics. (2011)

Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P & Vidal M. Next-generation sequencing to generate interactome datasets. Nature Methods. (2011)

Han BK & SD Emr. Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1. Genes Dev. (2011)

Fasolo J, Sboner A, Sun MG, Yu H, Chen R, Sharon D, Kim PM, Gerstein M, Snyder M. Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Genes Dev. (2011)

Ohouo, PY & Smolka, MB. A touching moment for Smc5/6: from ssDNA binding to repair. Cell Cycle. (2011)

Stefan, CJ, A Manford, D Baird, J Yamada-Hanff & SD Emr. Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Cell. (2011)

Lalonde, D & Bretscher, A. The UBX Protein SAKS1 negatively regulates Endoplasmic Reticulum-Associated Degradation and p97-dependent degragation. J. Biol. Chem. (2011)

Santiago-Tirado, F, Legesse-Miller, A, Schott, D & Bretscher, A. PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast. Developmental Cell. (2011)

Brady OA, Meng PS, Zheng Y, Mao Y & Hu F. Regulation of TDP-43aggregation by phosphorylation and p62/SQSTM1. Journal of Neurochemistry. (2011)



Basso LR Jr, Bartiss A, Mao Y, Gast CE, Coelho PS, Snyder M, Wong B. Transformation of Candida albicans with a synthetic hygromycin B resistance gene. Yeast. (2010)

Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A & Strittmatter SM. Sortilin1-Mediated Endocytosis Determines Levels of the Fronto-Temporal Dementia Protein. Progranulin Neuron. (2010)

Mao Y, Wei G. A Feedback-Based Secure Path Approach for Wireless Sensor Network Data Collection. Sensors (Basel). (2010)

Garbett, D, Lalonde, D & Bretscher, A. The Scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner. J. Cell Biol. (2010)

Ohouo, P, Oliveira, FM, Almeida, BS & Smolka, MB. DNA Damage Signaling Recruits the Rtt107-Slx4 Scaffolds via Dpb11 to Mediate Replication Stress Response. Mol. Cell. (2010)

Basso LR Jr, Gast CE, Mao Y, Wong B. Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p. Eukaryot Cell. (2010)

Garrenton, L, CJ Stefan, MA McMurray, SD Emr & J Thorner. Pheremone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.Proc. Natl. Acad. Sci. U.S.A. (2010)

Manford, A, T Xia, AK Saxena, CJ Stefan, F Hu, SD Emr & Y Mao. Crystal structure of the yeast Sac1: implication for its phosphoinositide phosphatase function. EMBO J. (2010)

Lalonde, D, Garbett, D & Bretscher, A. A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization. Mol. Cell Biol. (2010)

Gao, L, Liu, W & Bretscher, A. The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures. Mol. Biol. Cell. (2010)

Fehon, RG, McClatchey, AI & Bretscher, A. Organizing the Cell Cortex: The role of ERM proteins. Nature Reviews Molecular Cell Biol. (2010)

Teis, D, S Saksena, BL Judson & SD Emr. ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. EMBO J. (2010)

Smolka, MB. Fine-tuning the DNA damage response: protein phosphatase 2A checks on CHK2. Cell Cycle. (2010)



Emr S, Glick BS, Linstedt AD, Lippincott-Schwartz J, Luini A, Malhotra V, Marsh BJ, Nakano A, Pfeffer SR, Rabouille C, Rothman JE, Warren G, Wieland FT. Journeys through the Golgi--taking stock in a new era. J Cell Biol. (2009)

Tran JH, Chen CJ, Emr S, Schekman R. Cargo sorting into multivesicular bodies in vitro. PNAS. (2009)

Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J. (2009)

Gao L, Bretscher A. Polarized growth in budding yeast in the absence of a localized formin. Mol Biol. Cell. (2009)

Ilani T, Vasiliver-Shamis G, Vardhana S, Bretscher A, Dustin ML. T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immonol. (2009)

Bretscher A. Epithelial polarity: dual Lkb1 pathways regulate apical microvilli. Dev. Cell. (2009)

Teis D, Saksena S, Emr SD. SnapShot: the ESCRT machinery. Cell. (2009)

LaLonde DP, Bretscher A. The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50. Biochemistry. (2009)

Saksena S, Emr SD. ESCRTs and human disease. Biochem. Soc. Trans. (2009)

Saksena S, Wahlman J, Teis D, Johnson AE, Emr SD. Functional reconstitution of ESCRT-III assembly and disassembly. Cell. (2009)

Wagner MV, Smolka MB, de Bruin RA, Zhou H, Wittenberg C, Dowdy SF. Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae. PLoS One. (2009)